Publications
2025
Inagaki T, Kumar A, Wang KH, Komaki S, Espera JM, Bautista CSA, Nakajima KI, Izumiya C, Izumiya Y. (2025) Studies on Gene Enhancer with KSHV mini-chromatin. bioRxiv 2025.03.24.6449; doi: https://doi.org/10.1101/2025.03.24.644916
Inagaki T, Espera JM, Wang KH, Komaki S, Nair S, Davis RR, Kumar A, Nakajima KI, Izumiya Y. (2025) Design, development, and evaluation of gene therapeutics specific to KSHV-associated diseases. bioRxiv 2025.02.19.639178; doi: https://doi.org/10.1101/2025.02.19.639178
2024
Komaki S, Inagaki T, Kumar A, Izumiya Y. (2024) The Role of vIL-6 in KSHV-Mediated Immune Evasion and Tumorigenesis. Viruses, 16(12): 1900.
Miura H, Wang KH, Inagaki T, Chuang F, Shimoda M, Izumiya C, Watanabe T, Davis RR, Tepper CG, Komaki S, Nakajima K-i, Kumar A, Izumiya Y. (2024) A LANA peptide inhibits tumor growth by inducing CHD4 protein cleavage and triggers cell death. Cell Chemical Biology, 31(11): 1909-1925.
Inagaki T, Kumar A, Komaki S, Nakajima KI, Izumiya Y. (2024) An atlas of chromatin landscape in KSHV-infected cells during de novo infection and reactivation. Virology, 597: 110146.
Izumiya Y, Algalil A, Espera JM, Miura H, Izumiya C, Inagaki T, Kumar A. (2024) Kaposi's sarcoma-associated herpesvirus terminal repeat regulates inducible lytic gene promoters. Journal of Virology, 98(2): e0138623.
Nakajima K-i, Inagaki T, Espera JM, Izumiya Y. (2024) Kaposi's sarcoma-associated herpesvirus (KSHV) LANA prevents KSHV episomes from degradation. Journal of Virology, 98(2): e0126823.
2023
Shimoda M, Inagaki T, Davis RR, Merleev A, Tepper CG, Maverakis E, Izumiya Y. (2023) Virally encoded interleukin-6 facilitates KSHV replication in monocytes and induction of dysfunctional macrophages. PLoS Pathogens, 19(10): e1011703.
Inagaki T, Wang KH, Kumar A, Izumiya C, Miura H, Komaki S, Davis RR, Tepper CG, Katano H, Shimoda M, Izumiya Y. (2023) KSHV vIL-6 enhances inflammatory responses by epigenetic reprogramming. PLoS Pathogens, 19(11): e1011771.
2022
Kumar A, Lyu Y, Yanagihashi Y, Chantarasrivong C, Majerciak V, Salemi M, Wang KH, Inagaki T, Chuang F, Davis RR, Tepper CG, Nakano K, Izumiya C, Shimoda M, Nakajima KI, Merleev A, Zheng ZM, Campbell M, Izumiya Y. (2022) KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4. Cell Reports, 39(6): 110788.
Campbell M, Chantarasrivong C, Yanagihashi Y, Inagaki T, Davis RR, Nakano K, Kumar A, Tepper CG, Izumiya Y. (2022) KSHV Topologically Associating Domains in Latent and Reactivated Viral Chromatin. Journal of Virology, 96(14): e0056522.
Merleev AA, Le ST, Alexanian C, Toussi A, Xie Y, Marusina AI, Watkins SM, Patel F, Billi AC, Wiedemann J, Izumiya Y, Kumar A, Uppala R, Kahlenberg JM, Liu FT, Adamopoulos IE, Wang EA, Ma C, Cheng MY, Xiong H, Kirane A, Luxardi G, Andersen B, Tsoi LC, Lebrilla CB, Gudjonsson JE, Maverakis E. (2022) Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes. JCI Insights, 7(16):e159762.
Merleev A, Ji-Xu A, Toussi A, Tsoi LC, Le ST, Luxardi G, Xing X, Wasikowski R, Liakos W, Brüggen MC, Elder JT, Adamopoulos IE, Izumiya Y, Leal AR, Li Q, Kuzminykh NY, Kirane A, Marusina AI, Gudjonsson JE, Maverakis E. (2022) Proprotein convertase subtilisin/kexin type 9 is a psoriasis-susceptibility locus that is negatively related to IL36G. JCI Insights, 7(16):e141193.
2021
Shimoda M, Lyu Y, Wang KH, Kumar A, Miura H, Meckler JF, Davis RR, Chantarasrivong C, Izumiya C, Tepper CG, Nakajima K-i, Tuscano J, Barisone G, Izumiya Y. (2021) KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth. Commun Biol, 4(1): 1330.
Kumar A, Salemi M, Bhullar R, Guevara-Plunkett S, Lyu Y, Wang KH, Izumiya C, Campbell M, Nakajima K-i, Izumiya Y. (2021) Proximity Biotin Labeling Reveals KSHV Interferon Regulatory Factor Networks. Journal of Virology, 95(9):e2049-2.
Liao Y, Lupiani B, Izumiya Y, Reddy SM. (2021) Marek's disease virus Meq oncoprotein interacts with chicken HDAC 1 and 2 and mediates their degradation via proteasome dependent pathway. Scientific Reports, 11: 637.
Liao Y, Lupiani B, Bajwa K, Khan OA, Izumiya Y, Reddy SM. (2021) Role of Marek's Disease Virus (MDV)-Encoded US3 Serine/Threonine Protein Kinase in Regulating MDV Meq and Cellular CREB Phosphorylation. Journal of Virology, 94(17): e00892-20.
2020
Campbell M & Izumiya Y. (2020) PAN RNA: transcriptional exhaust from a viral engine. Journal of Biomedical Science, 27: 41.
Nakajima K-i, Guevara-Plunkett S, Chuang F, Wang KH, Lyu Y, Kumar A, Luxardi G, Izumiya C, Soulika A, Campbell M, Izumiya Y. (2020) Rainbow-KSHV Revealed Heterogenic Replication with Dynamic Gene Expression. Journal of Virology. 94(8):e01565-19
2019
Zhou F, Liu X, Gao L, Zhou X, Cao Q, Niu L, Wang J, Zuo D, Li X, Yang Y, Hu M, Yu Y, Tang R, Lee BH, Choi BW, Wang Y, Izumiya Y, Xue M, Zheng K, Gao D. (2019) HIV-1 Tat enhances purinergic P2Y4 receptor signaling to mediate inflammatory cytokine production and neuronal damage via PI3K/Akt and ERK MAPK pathways. J Neuroinflammation 16(1):71
Wang HJ, Pochampalli M, Wang LY, Zou JX, Li PS, Hsu SC, Wang BJ, Huang SH, Yang P, Yang JC, Chu CY, Hsieh CL, Sung SY, Li CF, Tepper CG, Ann DK, Gao AC, Evans CP, Izumiya Y, Chuu CP, Wang WC, Chen HW, Kung HJ. (2019) KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC. Oncogene 38(1):17-32
2018
Campbell M, Watanabe T, Nakano K, Davis RR, Lyu Y, Tepper CG, Fujimuro M, Izumiya Y. (2018) KSHV Chromatin Looping Facilitates Effective Gene Expression: Gene Cluster Activation via Direct K-Rta Binding at a Viral Chromatin Hub. Nature Communications, 9(1): 49.
Chen CP, Chuang F, Izumiya Y. (2018) Functional Imaging of Viral Transcription Factories using 3D Fluorescence Microscopy. Journal of Visualized Experiments, (131) e56832.
Zhou F, Liu X, Zuo D, Xue M, Gao L, Yang Y, Wang J, Niu L, Cao Q, Li X, Hua H, Zhang B, Hu M, Gao D, Zheng K, Izumiya Y, Tang R. (2018) HIV-1 Nef-induced lncRNA AK006025 regulates CXCL9/10/11 cluster gene expression in astrocytes through interaction with CBP/P300. J Neuroinflammation 15(1):303
2017
Chen CP, Lyu Y, Chuang F, Nakano K, Izumiya C, Jin D, Campbell M, Izumiya Y. (2017) Kaposi’s Sarcoma-associated Herpesvirus Hijacks RNA Polymerase II to Create a Viral Transcriptional Factory. Journal of Virology, 91(11): e02491-16.
Campbell M, Chen CP, Izumiya Y. (2017) KSHV episomes: rugged individualists on the factory floor. RNA and Disease, 4: e1565.
Zhou F, Shimoda M, Olney L, Tran K, Jiang G, Lyu Y, Nakano K, Tepper CG, Maverakis EM, Campbell M, Li Y, Dandekar S, Izumiya Y. (2017) Oncolytic Reactivation of KSHV as a Therapeutic Approach for Primary Effusion Lymphoma. Molecular Cancer Therapeutics 16(11):2627-2638.
Lyu Y, Nakano K, Davis RR, Tepper CG, Campbell M, Izumiya Y. (2017) Zic2 Is Essential for Polycomb-Mediated Maintenance of KSHV Latency and a Target of K-Rta. Journal of Virology, 91(21): e00980-17.